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郭慧淑

郭慧淑
所属科室:
中西医结合基础
职称:
*
出诊时间:
专家先容:
教授,博士研究生导师, 2004年获得博士学位,同年赴美国University of Illinois at Urbana-Champaign做访问学者,在美期间主要进行胃肠动力药物开发方面的研究。2012年入选辽宁省高等学校优秀人才计划。2013年入选大连医科大学英才工程计划优秀人才支撑计划,现任职于bet官网365入口-28365365备用官网中心实验室副主任,大连市消化系统疾病重点实验室主任。主持并参与多项国家级省市课题,发表 SCI论文20余篇。获得市科技进步一等奖一项,二等奖一项,省科技进步二等奖两项。部分科研成果被18届欧洲胃肠病年会上展示,并被GUT收入。 兼世界中医药联合会理事、中国生理学会消化与营养专业委员会委员、中华医学生物免疫学会委员等职务。 研究方向 主要研究方向: 1.中西医结合胃肠动力方面的研究:胃肠动力与离子通道之间的关系,研究钙敏感钾电流、抑制延迟整流型钾电流和钙电流在胃肠动力调节中的作用及中西医结合治疗; 2.Fe3O4纳米晶超晶格磁共振与染色一体介导下对直肠癌淋巴转移的光热治疗 3.中西医结合治疗结直肠癌的基础与临床研究 在研主持: 1.国家自然科学基金面上项目:肝郁脾虚证大鼠胃肠钠尿肽信号通路的变化及疏肝健脾法干预机制(81273919) 项目负责人。 2.国家科技部重大科学研究计划“973”项目:从胃肠动力角度探讨从“脾论治”FD及功能性腹泻的效应机制(2013HZ114)。 3.辽宁省自然科学基金:钠尿肽信号通路对抑郁大鼠胃运动的调控及疏肝健脾法的干预机制(2013023002) 项目负责人 4.辽宁省高等学校优秀人才支撑计划: 钠尿肽信号通路上调引起胃肠运动障碍及逍遥散的干预作用(LJQ2013094) 项目负责人 代表文章 1.Zheng Xu Cai, Xu Dong Tang, He Li Gao, Chuanning Tang, Vijayalakshmi Nandakumar, Lindsey Jones, and Hui Shu Guo*.APC, FBXW7, KRAS, PIK3CA, and TP53 gene mutations in human colorectal cancer tumors frequently detected by Next-Generation DNA. Journal of Molecular and Genetic Medicine, 2015,4(8):1-11 2.Zheng Xu Cai , Xu dong Tang, Feng yun Wang, Zhi jun Duan, Yu chun Li, Juan juan Qiu, Hui shu Guo*. Effect of gingerol on colonic motility via inhibition of calcium channel current. World Journal of Gastroenterology,2015(accepted). 3.Zheng-Xu Cai , Hui-Shu Guo , Che Wang , Min Wei, Cheng Cheng , Zhao-Fei Yang, Yin-Wang Chen, Wei-Dong Le, Song Li. Double-edged roles of nitric oxide signaling on APP processing and amyloid-β production in vitro: Preliminary evidence from sodium nitroprusside. Neurotox Res. 2015 Oct 1 Epub ahead of print] 4.Ge liang Liu, Chao Wang, Hailong Chen, Jingwen Zhang, Hui shu Guo*, Effects and mechanisms of alveolar type II epithelial cell apoptosis in severe pancreatitis-induced acute lung injury. Experimental and Therapeutic Medicine 2014,3(7):565-572. 5.Li P, Tang XD, Cai ZX, Qiu JJ, Lin XL, Zhu T, Owusu L, Guo HS*.CNP signal pathway up-regulated in rectum of depressed rats and the interventional effect of Xiaoyaosan. World Journal of Gastroenterology 2014,5(21):1518-1530 6.Yin L, Guo H*, Zhao L, Wang J. The programmed death-1 gene polymorphism (PD-1.5 C/T) is associated with non-small cell lung cancer risk in a Chinese Han population. International Journal of Clinical and Experimental Medicine 2014,12(7):5832-5836. 7.Choi YH, Jin GY, Guo HS, Piao HM, Li Lc, Li GZ, Lin ZH, Yan GH. Silibinin attenuates allergic airway inflammation in mice. 2012. Biochem Biophys Res Commun. 2012 Oct 26;427(3):450-5. 8.Shu-Ying Zhang, Zheng-Xu Cai, Ping Li, Chun-Yu Cai, Cheng-Long Qu , Hui-Shu Guo* Effect of dendroaspis natriuretic peptide (DNP) on L-type calcium channel current and its pathway. Regulatory Peptides. 2010; 164: 120–125. 9.Qi QH, Li Y, Yao CH, Liang GG, Guo HS.Morphological changes in network of enteric nerve-interstitial cells of Cajal-smooth muscle cells in rats with multiple organ dysfunction syndrome and therapeutic effects of Dachengqi decoction. Chin J Integr Med. 2010 ;16(5):422-9. 10.Guo HS*, Cai ZX, Zhang SY. Effect of dendroaspis natriuretic peptide (DNP) on L-type calcium channel current in gastric antral circular smooth muscle of guinea-pig.GUT2010;59P0703. Abstract (18th United European Gastroentelogy Week, Barcelona 2010) 11.Gu XY, Cai ZX, Yuan H, Wu TH, Li J, Guo HS* Effects of Dendroaspis natriuretic peptide on delayed rectifier potassium currents and its mechanism.Regul Pept. 2009;155(1-3):115-120. 12.Cai CY, Cai ZX, Gu XY, Shan LJ, Wang YX, Yin XZ, Qi QH, Guo HS*. Dendroaspis natriuretic peptide relaxes gastric antral circular smooth muscle of guinea-pig through the cGMP/cGMP-dependent protein kinase pathway. World J Gastroenterol.2008;14(35):5461-5466. 13.Guo HS*, Yang YZ, Zou Y, Xu J, Cai ZX, Qi QH. Effects of dendroaspis natriuretic peptide on calcium-activated potassium current and its mechanism. J Physiol Sci. 2008;58(1):1-6. 14.Guo HS*, Cai ZX, Wu TH, Xu J, Qiu Y, Xu WX. Inhibitory effect of dendroaspis natriuretic peptide on spontaneous contraction in gastric antral circular smooth muscles of guinea pigs.Acta Pharmacol Sin. 2007;28(11):1797-1802. 15.Hui-Shu Guo, Zheng-Jin, Zheng-Yuan Jin, Zhe-Hao Li, Yi-Feng Cui, Zuo-Yu Wang,Wen-Xie Xu. Comparative study in the effect of C-type natriuretic peptide on gastric motility in various animals. World J Gastroenterol. 2003;9(3):547-552. 16.Guo Hui-Shu, Cui Xun, Cui Yong-gen, Kim Sung-Zoo, Cho Kyung-Woo, LI Zai-Liu, XU Wen-Xie. Inhibitory effect of C-type natriuretic peptide on spontaneous contraction in gastric antral circular smooth muscle of rat. Acta Pharmacol Sin. 2003;24(10):1021-1026. 17.Hui-Shu Guo, Zheng-Xu Cai, Hai-Feng Zheng, Xiang-Lan Li, Yi-Feng Cui, Zuo-Yu Wang, Wen-Xie Xu Role of calcium-activated potassium current in CNP-induced relaxation of gastric circular smooth muscle in guinea-pigs. World J Gastroenterol 2003;9(9):2054-2059. 获奖情况: 1 辽宁省科技进步三等奖(2011J-3-103-01):胃动力障碍性疾病中钠尿肽系统的作用机制及实验性干预 郭慧淑;蔡正旭;张曙影;蔡春玉;谷新衣;李艳艳;闻庆平 2 大连市科技进步二等奖(2010J-2-20-01):胃动力障碍性疾病中钠尿肽系统的作用机制及实验性干预 郭慧淑;蔡正旭;张曙影;蔡春玉;谷新衣;李艳艳;闻庆平 3 大连市科技进步一等奖(2008J-1-09-08):大承气汤治疗胃肠运动障碍疾病的临床和基础研究 齐清会;李毅;梁国刚;战丽彬;林虹;尚东;王长淼;郭慧淑;张栋梁;周丽 4 吉林省科技进步二等奖(2008J20036):cGMP信号通路对胃平滑肌运动调空及其离子通道机制研究 许文燮;金元哲;金政;崔勋;吴龙仁;许东元;郭慧淑;李香兰;李春晖;徐慧颖;金正;兰艳 5 辽宁省科技进步二等奖(2009J-2-62-05 ): 肺纤维化中基质金属蛋白酶系统的作用及信号传导机制 吴泰华;林洪丽;唐海英;杨冬;郭慧淑;刘越坚;高丽丽;周广民;曲承春;单露娟;邱阳;郭莉 联系方式 电子邮箱:guohuishu1@126.com 电话:18098877626

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